Importantly, an ERRα signature in prostate cancer recapitulates the prognostic features of PGC1A. The following is Supplementary data to this article: ZIP. LZIP, Luman, C80076, LZIP-1, LZIP-2, AU044960, AW538053 cAMP responsive element binding protein 3 NM011957 Creb3l1 GXA00045874 Oasis, MGC25246 cAMP responsive element binding protein 3-like 1 NM178661 Creb3l2 GXA00018119 BBF2H7, C530025K05Rik cAMP responsive element binding protein 3-like 2 NM145365 Creb3l3 GXA00017925 CREB-H, BC010786. This metabolic program is regulated downstream the Oestrogen-related receptor alpha (ERRα), and PGC1α mutants lacking ERRα activation capacity lack metabolic rewiring capacity and metastasissuppressive function. Voluntary wheel running improves skeletal muscle PGC-1a/IDO1 signals and hippocampal function. thermogenesis (Pgc1a and Ucp1) in brown adipose tissue (Ferron et al., 2008). Through the application of integrative metabolomics and transcriptomics we demonstrate that PGC1α expression in prostate cancer is sufficient to elicit a global metabolic rewiring that opposes cell growth, consisting of sustained oxidative metabolism at the expense of anabolism. such as ZRT/IRT-like Protein (ZIP) 14 (Liuzzi et al., 2006). Uniprot Gene hsa:1 P04217 A1BG hsa:10 A4Z6T7 NAT2 hsa:10 P11245 NAT2 AAC2 hsa:100 A0A0S2Z381 ADA hCG38105 hsa:100 P00813 ADA ADA1 hsa:1000 A0A024RC42 CDH2 hCG22518 hsa:1000 P19022 CDH2 CDHN NCAD hsa:10000 Q9Y243 AKT3 PKBG hsa:100008586 O76087 GAGE7 GAGE12I GAGE7B hsa:100008586 P0CL80 GAGE12F hsa:100008586 P0CL81 GAGE12G hsa:100008586 P0CL82 GAGE12I hsa:10001 O75586 MED6 ARC33 hsa:10002. Genetically engineered mouse model studies revealed that compound prostate epithelium-specific deletion of Pgc1a and Pten promotes prostate cancer progression and metastasis, whereas, conversely, PGC1α expression in cell lines inhibits the pre-existing metastatic capacity. A metabolic co-regulator data mining analysis unveiled that PGC1α is consistently down-regulated in multiple prostate cancer patient datasets and its alteration is associated with reduced disease-free survival and metastasis. The file in this repository named contains all 69 genes in the experiment and their correlations to the compounds in the experiment (the. Here we show that the transcriptional co-activator PGC1α suppresses prostate cancer progression and metastasis. Master co-regulators of metabolism orchestrate the modulation of multiple metabolic pathways through transcriptional programs, and hence constitute a probabilistically parsimonious mechanism for general metabolic rewiring. The current view of cellular transformation and cancer progression supports the notion that cancer cells must reprogram their metabolism in order to survive and progress in different microenvironments.
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